Writing in the journal Experimental Biology and Medicine a team of scientists from the University of Bath, UK, lead by Dr. Sarah Bailey of the Department of Pharmacy & Pharmacology, reported on their discovery that the drug, also known as Accutane, reduced the availability of the neurotransmitter serotonin; low levels of which have consistently been linked to a number of psychiatric symptoms including aggression, anxiety disorders, and suicidal ideation.
"Serotonin is an important chemical that relays signals from nerve cells to other cells in the body", said Dr. Bailey, "our findings suggest that Roaccutane might disrupt the way serotonin is produced and made available to cells…this could result in problems associated with low levels of serotonin, which might include depression".
Previous Research
Previous research by the same scientists, suggested that the drug caused depressive behaviour in mice; but until now an underlying reason for the link has remained elusive, despite a history of tragic suicide deaths associated with its use.
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